TCT-152 ALLogeneic Heart STem Cells To Achieve Myocardial Regeneration (ALLSTAR): The Six Month Phase I Safety Results
نویسندگان
چکیده
منابع مشابه
Stem cells for myocardial regeneration.
Stem cells are being investigated for their potential use in regenerative medicine. A series of remarkable studies suggested that adult stem cells undergo novel patterns of development by a process referred to as transdifferentiation or plasticity. These observations fueled an exciting period of discovery and high expectations followed by controversy that emerged from data suggesting cell-cell ...
متن کاملStem cells and myocardial regeneration.
A remarkable paradigm shift is occurring in our understanding of organ regeneration that may have significant therapeutic implications. Conventionally, the heart is perceived as a terminally differentiated organ incapable of regeneration. It is thought that the myocytes respond to physiologic or pathologic stress only by hypertrophy, but not by increase in number. However, recent evidence sugge...
متن کاملStem Cells and Myocardial Regeneration
Correspondence: E. Michael Molnar Bio-Cellular Research Organization, 113 Barksdale Professional Center, Newark, DE 19711, USA E-mail:[email protected] Cardiomyocytes lose their ability to proliferate after birth and so heart muscle fibers cannot regenerate. For that reason myocardial injury, such as myocardial infarction (MI), heals by replacement of contractile heart musc...
متن کاملStrategies to Improve Homing of Stem Cells to achieve better Efficacy in Stem Cell Therapy
Stem/progenitor cell based therapeutic approach in our daily routine clinical practice, has been elusive dream in medical sciences and improvement of stem cell homing as one of major challenges in cell therapy programs, has been considered a promising milestone. It has been proved that stem/progenitor cells exhibit a homing response to injured tissues/organs, mediated by interactions of chemoki...
متن کاملMyocardial regeneration by adult stem cells.
Ventricular remodeling and heart failure are the inevitable consequences of myocardial infarction. Current options to cure myocardial infarction and subsequent heart failure suffer from specific limitations. Thus, alternative, additional long-term therapeutic strategies are needed to cure this costly and deadly disease. Cardiac regeneration is a promising new therapeutic option. Through cellula...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2014
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2014.07.188